Gene information
Official symbol TGFBR1
Official full name transforming growth factor beta receptor 1
Gene type protein-coding gene
Chromosome9q22.33
Alias symbolALK-5|ACVRLK4|ALK5|TBRI|TBR-i
Previous symbolMSSE|ESS1
Gene familyType 1 receptor serine/threonine kinases
Resources
Entrez Gene 7046
HGNC HGNC:11772
Ensembl ENSG00000106799
Vega OTTHUMG00000020353
UCSC uc004azc.4
GO terms: 173 records
GO Description Category LogP Number of genes Detail
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001667 ameboidal-type cell migration GO Biological Processes -17.0771232 40 More
GO:0001701 in utero embryonic development GO Biological Processes -8.76987260 44 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001822 kidney development GO Biological Processes -16.2664835 49 More
GO:0001837 epithelial to mesenchymal transition GO Biological Processes -7.70350405 17 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001938 positive regulation of endothelial cell proliferation GO Biological Processes -32.0012114 45 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0003002 regionalization GO Biological Processes -7.48750854 38 More
GO:0003007 heart morphogenesis GO Biological Processes -18.8519524 49 More
GO:0003205 cardiac chamber development GO Biological Processes -16.2154327 37 More
GO:0003206 cardiac chamber morphogenesis GO Biological Processes -17.7982686 34 More
GO:0003208 cardiac ventricle morphogenesis GO Biological Processes -12.9810396 22 More
GO:0003229 ventricular cardiac muscle tissue development GO Biological Processes -12.2262922 19 More
GO:0003231 cardiac ventricle development GO Biological Processes -15.0525208 31 More
GO:0003279 cardiac septum development GO Biological Processes -6.36759289 18 More
GO:0003281 ventricular septum development GO Biological Processes -5.74246280 14 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0004675 transmembrane receptor protein serine/threonine kinase activity GO Molecular Functions -3.49893214 3 More
GO:0005024 transforming growth factor beta receptor activity GO Molecular Functions -4.01518900 3 More
GO:0005114 type II transforming growth factor beta receptor binding GO Molecular Functions -5.24494293 4 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005160 transforming growth factor beta receptor binding GO Molecular Functions -4.37707433 7 More
GO:0005911 cell-cell junction GO Cellular Components -3.41801827 38 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -8.77828157 29 More
GO:0007179 transforming growth factor beta receptor signaling pathway GO Biological Processes -7.95704539 19 More
GO:0007276 gamete generation GO Biological Processes -2.03816629 18 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007517 muscle organ development GO Biological Processes -15.8908392 49 More
GO:0007548 sex differentiation GO Biological Processes -7.13021119 33 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0008406 gonad development GO Biological Processes -5.85435513 14 More
GO:0008584 male gonad development GO Biological Processes -2.74541064 14 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009791 post-embryonic development GO Biological Processes -4.81501809 14 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0009952 anterior/posterior pattern specification GO Biological Processes -5.02972741 24 More
GO:0010631 epithelial cell migration GO Biological Processes -10.0481870 21 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010717 regulation of epithelial to mesenchymal transition GO Biological Processes -12.1292389 25 More
GO:0010718 positive regulation of epithelial to mesenchymal transition GO Biological Processes -11.466629 18 More
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO Biological Processes -7.11509809 13 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0014706 striated muscle tissue development GO Biological Processes -21.0654252 44 More
GO:0016301 kinase activity GO Molecular Functions -2.42130611 19 More
GO:0019199 transmembrane receptor protein kinase activity GO Molecular Functions -5.31743835 14 More
GO:0019838 growth factor binding GO Molecular Functions -18.6841278 23 More
GO:0019955 cytokine binding GO Molecular Functions -19.1485102 24 More
GO:0030198 extracellular matrix organization GO Biological Processes -21.4880730 33 More
GO:0030199 collagen fibril organization GO Biological Processes -7.34609657 9 More
GO:0030307 positive regulation of cell growth GO Biological Processes -13.7154299 34 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031346 positive regulation of cell projection organization GO Biological Processes -6.78114948 37 More
GO:0032231 regulation of actin filament bundle assembly GO Biological Processes -4.42971140 15 More
GO:0032330 regulation of chondrocyte differentiation GO Biological Processes -3.54364153 9 More
GO:0032331 negative regulation of chondrocyte differentiation GO Biological Processes -3.67847337 4 More
GO:0032956 regulation of actin cytoskeleton organization GO Biological Processes -4.25470878 32 More
GO:0032970 regulation of actin filament-based process GO Biological Processes -7.72273150 43 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035270 endocrine system development GO Biological Processes -10.2307745 25 More
GO:0036314 response to sterol GO Biological Processes -7.24411974 11 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0043009 chordate embryonic development GO Biological Processes -11.8113315 68 More
GO:0043062 extracellular structure organization GO Biological Processes -21.4370160 33 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043542 endothelial cell migration GO Biological Processes -10.6625063 19 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045137 development of primary sexual characteristics GO Biological Processes -5.73912217 14 More
GO:0045165 cell fate commitment GO Biological Processes -15.5778047 44 More
GO:0045229 external encapsulating structure organization GO Biological Processes -21.3355594 33 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0046546 development of primary male sexual characteristics GO Biological Processes -2.71532895 14 More
GO:0046620 regulation of organ growth GO Biological Processes -13.2396968 26 More
GO:0046661 male sex differentiation GO Biological Processes -3.36897940 17 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048538 thymus development GO Biological Processes -2.59334716 7 More
GO:0048562 embryonic organ morphogenesis GO Biological Processes -8.59880895 37 More
GO:0048568 embryonic organ development GO Biological Processes -17.1204114 64 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048644 muscle organ morphogenesis GO Biological Processes -13.8992054 24 More
GO:0048705 skeletal system morphogenesis GO Biological Processes -7.04838258 29 More
GO:0048706 embryonic skeletal system development GO Biological Processes -2.56739645 13 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0048738 cardiac muscle tissue development GO Biological Processes -21.5979622 44 More
GO:0048762 mesenchymal cell differentiation GO Biological Processes -16.1250183 37 More
GO:0048844 artery morphogenesis GO Biological Processes -13.4119116 22 More
GO:0048880 sensory system development GO Biological Processes -3.47450215 31 More
GO:0050431 transforming growth factor beta binding GO Molecular Functions -4.79620345 5 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0050680 negative regulation of epithelial cell proliferation GO Biological Processes -26.5961536 48 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051492 regulation of stress fiber assembly GO Biological Processes -3.91249954 13 More
GO:0051493 regulation of cytoskeleton organization GO Biological Processes -3.52271067 40 More
GO:0051495 positive regulation of cytoskeleton organization GO Biological Processes -3.67944181 20 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0055008 cardiac muscle tissue morphogenesis GO Biological Processes -12.6682372 20 More
GO:0055010 ventricular cardiac muscle tissue morphogenesis GO Biological Processes -11.5275821 17 More
GO:0055021 regulation of cardiac muscle tissue growth GO Biological Processes -9.70685856 18 More
GO:0060037 pharyngeal system development GO Biological Processes -4.73205562 8 More
GO:0060043 regulation of cardiac muscle cell proliferation GO Biological Processes -6.20215763 12 More
GO:0060317 cardiac epithelial to mesenchymal transition GO Biological Processes -3.03394175 6 More
GO:0060389 pathway-restricted SMAD protein phosphorylation GO Biological Processes -7.32764136 8 More
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation GO Biological Processes -7.52187520 15 More
GO:0060411 cardiac septum morphogenesis GO Biological Processes -7.50725768 16 More
GO:0060412 ventricular septum morphogenesis GO Biological Processes -5.14667380 10 More
GO:0060415 muscle tissue morphogenesis GO Biological Processes -13.8643925 23 More
GO:0060420 regulation of heart growth GO Biological Processes -10.7642352 20 More
GO:0060485 mesenchyme development GO Biological Processes -18.0238 46 More
GO:0060491 regulation of cell projection assembly GO Biological Processes -2.36338574 17 More
GO:0060537 muscle tissue development GO Biological Processes -18.3336784 54 More
GO:0060840 artery development GO Biological Processes -12.7697342 25 More
GO:0060976 coronary vasculature development GO Biological Processes -7.60302561 13 More
GO:0060977 coronary vasculature morphogenesis GO Biological Processes -6.32323278 8 More
GO:0060982 coronary artery morphogenesis GO Biological Processes -4.53812662 3 More
GO:0061035 regulation of cartilage development GO Biological Processes -4.43006301 12 More
GO:0061037 negative regulation of cartilage development GO Biological Processes -4.61361828 8 More
GO:0061061 muscle structure development GO Biological Processes -23.2569142 77 More
GO:0061383 trabecula morphogenesis GO Biological Processes -5.83082467 11 More
GO:0061384 heart trabecula morphogenesis GO Biological Processes -4.50023695 8 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0062042 regulation of cardiac epithelial to mesenchymal transition GO Biological Processes -8.11856573 7 More
GO:0062043 positive regulation of cardiac epithelial to mesenchymal transition GO Biological Processes -8.75560539 7 More
GO:0070723 response to cholesterol GO Biological Processes -8.11481650 11 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071559 response to transforming growth factor beta GO Biological Processes -17.0634996 37 More
GO:0071560 cellular response to transforming growth factor beta stimulus GO Biological Processes -16.8909657 36 More
GO:0072001 renal system development GO Biological Processes -17.7796243 52 More
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -13.1150464 44 More
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -10.5573443 25 More
GO:0090130 tissue migration GO Biological Processes -11.7623300 24 More
GO:0090132 epithelium migration GO Biological Processes -9.75855830 21 More
GO:0097305 response to alcohol GO Biological Processes -17.4096682 46 More
GO:0097435 supramolecular fiber organization GO Biological Processes -6.48496756 24 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0110020 regulation of actomyosin structure organization GO Biological Processes -4.68299748 15 More
GO:0110053 regulation of actin filament organization GO Biological Processes -3.93783734 26 More
GO:0120032 regulation of plasma membrane bounded cell projection assembly GO Biological Processes -2.40785708 17 More
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly GO Biological Processes -1.88939040 5 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:0150063 visual system development GO Biological Processes -3.59465978 31 More
GO:1902903 regulation of supramolecular fiber organization GO Biological Processes -5.63791156 37 More
GO:1902905 positive regulation of supramolecular fiber organization GO Biological Processes -5.32876142 22 More
GO:1904888 cranial skeletal system development GO Biological Processes -2.01258862 8 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001235 positive regulation of apoptotic signaling pathway GO Biological Processes -13.4065813 30 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO Biological Processes -19.1764933 21 More
KEGG pathways: 21 records
KEGG Description Category LogP Number of genes Detail
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04068 FoxO signaling pathway KEGG Pathway -6.87449445 21 More
hsa04218 Cellular senescence KEGG Pathway -5.14633043 11 More
hsa04350 TGF-beta signaling pathway KEGG Pathway -6.45304971 17 More
hsa04371 Apelin signaling pathway KEGG Pathway -6.49715749 12 More
hsa04380 Osteoclast differentiation KEGG Pathway -7.05199617 21 More
hsa04390 Hippo signaling pathway KEGG Pathway -3.46529255 17 More
hsa04659 Th17 cell differentiation KEGG Pathway -9.80516906 14 More
hsa04926 Relaxin signaling pathway KEGG Pathway -10.8215200 16 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
hsa05161 Hepatitis B KEGG Pathway -5.78517620 12 More
hsa05166 Human T-cell leukemia virus 1 infection KEGG Pathway -5.08552863 13 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05210 Colorectal cancer KEGG Pathway -3.02613520 11 More
hsa05212 Pancreatic cancer KEGG Pathway -2.89550682 10 More
hsa05220 Chronic myeloid leukemia KEGG Pathway -2.89550682 10 More
hsa05225 Hepatocellular carcinoma KEGG Pathway -5.07719186 21 More
hsa05226 Gastric cancer KEGG Pathway -5.33653529 20 More
hsa05415 Diabetic cardiomyopathy KEGG Pathway -11.4800633 20 More
Drug-Gene interaction
view
Related drugs: 6 records
Drug name Interaction type Source PMID View
chembl261454 inhibitor DTC 1903579210592235 view
galunisertib inhibitor ChemblInteractions view
hesperadin inhibitor DTC 19035792 view
ly-2382770 TTD view
metelimumab TTD view
vactosertib inhibitor TTD view
Related studies: 3 records
Molecular factor Omics type Application Objective MI type Reference
TGFBR1 transcriptomics left ventricular dysfunction[prognosis (bad)] acute myocardial infarction Boileau A et al. Int J Cardiol. 2018
TGF-beta receptor type-1 proteomics acetylcysteine[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Talasaz AH et al. Drugs R D. 2013
TGF-beta receptor type-1 proteomics medium predictor left ventricular dysfunction[prognosis (bad)] acute ST elevation myocardial infarction Devaux Y et al. BMC Med Genomics. 2011
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